This is just my opinion, but I imagine as a gimmick at the start it would probably be cool, but then you'll kinda get tired of it rather quickly as the colours are off and could be rather annoying maybe in the long run?
The blindness system instead that we have right now has an actual "cure" of either wearing glasses or curing it entirely with a Xen potion. The blurriness of the screen is rather horrendous, so people typically wear glasses all the time or when they create the character then they don't go with a character that has to wear them. Roleplaying wise the colour blindness on the other hand could be utilised, but as said at the start that it will probably tilt/piss you off eventually.